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Naproxcinod Does Not Raise Blood Pressu Hier à 22:22
Naproxcinod Does Not Raise Blood Pressure in Patients With Osteoarthritis: Presented at ASH(HYP)
By Roberta Friedman, PhD
SAN FRANCISCO -- May 9, 2009 -- Naproxcinod does not raise blood pressure in patients taking the drug to control pain from osteoarthritis, as compared with naproxen, according to a study presented here at the American Society of Hypertension (ASH) 24th Annual Scientific Meeting and Exposition.
Study investigator William B. White, MD, University of Connecticut School of Medicine, Farmington, Connecticut, noted in his talk on May 8 that cyclooxygenase inhibitor drugs interfere with the production of prostaglandins that are required to maintain renal blood flow.
Chronic use of these drugs can produce salt and water retention and can actually result in congestive heart failure and even kidney failure in some people. The risk is there, he said, "especially in older patients who may have both osteoporosis and hypertension."
The presented trial of naproxcinod resulted in less destabilisation of blood pressure as compared with naproxen, Dr. White said. Doses of naproxcinod tested were 375 and 750 mg BID and naproxen was given at 500 mg BID. The 13-week trial was double-blinded and placebo-controlled.
A total of 916 patients had osteoarthritis of the hip or knee, and had experienced worsening of their symptoms when withdrawn from their anti-inflammatory therapy, Dr. White said. Half of the patients were hypertensive, as evidenced by medical and treatment history, and of these, half were taking renin-angiotensin system inhibitors.
Patients' mean age was 61 years; 70% were women, and 86% were white. Mean body mass index (BMI) was 33. Baseline systolic pressures were similar in the 4 treatment groups, but were slightly higher in patients with hypertension.
Each group in the trial had about 230 participants; mean blood pressure at entry was 126/77 mm Hg.
At week 13, naproxcinod did not change systolic blood pressure from baseline as contrasted with a rise with naproxen (P = .015). In patients with hypertension, the proportion of patients whose systolic pressure increased by more than 10 mm Hg was greater on naproxen than on naproxcinod and placebo: 16% and 8.5% respectively for those taking renin-angiotensin blockers, Dr. White said.
Those taking naproxen had a 10% chance of raising systolic pressure above 140 at 13 weeks. Only a 5% chance of increasing blood pressure occurred for those taking naproxcinod (P = .046).
Funding for this study was provided by NicOx S.A.
[Presentation title: The Hypertensive Effects Observed With Traditional NSAIDs Are Less With the Cyclooxygenase Inhibiting Nitric Oxide Donator Naproxcinod in Patients With Osteoarthritis. Abstract OR-11]
Naproxcinod Does Not Raise Blood Pressu Hier à 22:22
Naproxcinod Does Not Raise Blood Pressure in Patients With Osteoarthritis: Presented at ASH(HYP)
By Roberta Friedman, PhD
SAN FRANCISCO -- May 9, 2009 -- Naproxcinod does not raise blood pressure in patients taking the drug to control pain from osteoarthritis, as compared with naproxen, according to a study presented here at the American Society of Hypertension (ASH) 24th Annual Scientific Meeting and Exposition.
Study investigator William B. White, MD, University of Connecticut School of Medicine, Farmington, Connecticut, noted in his talk on May 8 that cyclooxygenase inhibitor drugs interfere with the production of prostaglandins that are required to maintain renal blood flow.
Chronic use of these drugs can produce salt and water retention and can actually result in congestive heart failure and even kidney failure in some people. The risk is there, he said, "especially in older patients who may have both osteoporosis and hypertension."
The presented trial of naproxcinod resulted in less destabilisation of blood pressure as compared with naproxen, Dr. White said. Doses of naproxcinod tested were 375 and 750 mg BID and naproxen was given at 500 mg BID. The 13-week trial was double-blinded and placebo-controlled.
A total of 916 patients had osteoarthritis of the hip or knee, and had experienced worsening of their symptoms when withdrawn from their anti-inflammatory therapy, Dr. White said. Half of the patients were hypertensive, as evidenced by medical and treatment history, and of these, half were taking renin-angiotensin system inhibitors.
Patients' mean age was 61 years; 70% were women, and 86% were white. Mean body mass index (BMI) was 33. Baseline systolic pressures were similar in the 4 treatment groups, but were slightly higher in patients with hypertension.
Each group in the trial had about 230 participants; mean blood pressure at entry was 126/77 mm Hg.
At week 13, naproxcinod did not change systolic blood pressure from baseline as contrasted with a rise with naproxen (P = .015). In patients with hypertension, the proportion of patients whose systolic pressure increased by more than 10 mm Hg was greater on naproxen than on naproxcinod and placebo: 16% and 8.5% respectively for those taking renin-angiotensin blockers, Dr. White said.
Those taking naproxen had a 10% chance of raising systolic pressure above 140 at 13 weeks. Only a 5% chance of increasing blood pressure occurred for those taking naproxcinod (P = .046).
Funding for this study was provided by NicOx S.A.
[Presentation title: The Hypertensive Effects Observed With Traditional NSAIDs Are Less With the Cyclooxygenase Inhibiting Nitric Oxide Donator Naproxcinod in Patients With Osteoarthritis. Abstract OR-11]
vero DOC???
si lamentano che nicox è ferma a 9€ e che tutto sale ma non si ricordano di quanto sono scese certe azioni<<<<<<<<<<<<< guarda il grafico di cell a 8 anni, ora è salita da 0,05 cents ad 1€ ma solo sei mesi fa ne costava 1,4 e pochi anni fa ante i vari split 2000€ per azione
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