DickSIM
Prima o poi....ci becco!
Se la vostra perspicacia è uguale al "caso accumulazione continuata di Nicox quando era a 9 euro".......ho la matematica certezza dopo la tua battuta che è sicuramente e indubitabilmente ACCUMULAZIONE !!!
Pharma e Biotech - Europa NicOx : Quelli che aspettano ,,,, ridendo !!! (22 lettori)
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Naproxcinod (nitronaproxen) is a non-steroidal antiinflammatory drug (NSAID) developed by the French pharmaceutical company NicOx. It is derived from naproxen but substituted with a nitroxybutyl ester to allow it to also act as a nitric oxide (NO) donor. This second mechanism of action makes naproxcinod the first of a new class of drugs, the cyclooxygenase inhibiting nitric oxide donators (CINODs), that are hoped to produce similar analgesic efficacy to traditional NSAIDs, but with less gastrointestinal and cardiovascular side effects.[1][2]
On December 2006, Scientific American distinguished naproxcinod as one of the ten most promising treatments for the world's biggest health threats.[3]
Contents
[hide]
Many people are currently relying on traditional non-steroidal antiinflammatory drugs and COX-2 inhibitors (for example celecoxib) to treat chronic pain and inflammation. COX-2 inhibitors have been associated with an increased risk of serious cardiovascular events such as strokes or heart attacks.[4] Therefore, there is an unmet need for safer medications. This need is particularly acute among patients with high cardiovascular risk like hypertension which represents 50% of osteoarthritis sufferers.[citation needed]
[edit] Indications
Three phase III clinical trials led by NicOx have shown that naproxcinod was effective to treat pain against knee osteoarthritis[5][6][7] and hip osteoarthrtis[8]. A phase II study showed no significant differences in efficacy between naproxcinod and the COX-2 inhibitor rofecoxib in the treatment of pain.[9]
In osteoarthritis, a 750 mg dose is equipotent to 500 mg of naproxen for the treatment of inflammation but with the added benefit of attenuating the cardiovascular effects traditionally associated with NSAIDs.[10]
[edit] Mechanism of action
Naproxcinoid is metabolized to naproxen and a nitric oxide donating moiety. NO has various cardiovascular effects, including vasodilatory and platelet-inhibitory actions as well as the inhibition of vascular smooth muscle proliferation that serves to maintain normal vascular tone.[10]
[edit] Safety profile
[edit] Blood pressure profile
According to some experts[who?], cardiovascular risks induced by COX-2 inhibitors are caused by increases in blood pressure. Naproxcinod demonstrated in a clinical trial with 916 patients to have a blood pressure profile similar to placebo.[10] Two phase II randomized controlled trials have shown a decreased systolic blood pressure by 2.1 mmHg after patients took naproxcinod (375 mg or 750 mg twice daily) for six weeks. These effects were especially pronounced in hypertensive populations.[9][11]
[edit] Clinical relevance of small increase in blood pressure
During an U.S. Food and Drug Administration (FDA) COX-2 advisory committee meeting, doctors have underlined the important role of small increase in blood pressure.[12] They cited the CAMELOT trial which has concluded that even a small decrease in systolic blood pressure of 5 mmHg could lead to a reduction of 31% in cardiovascular events.[13] Clinical studies about rofecoxib have shown that this drug increases the systolic blood pressure.[14]
A 2005 analysis shows that a blood pressure decrease of 3.1 mmHG could avoid over 30,000 deaths from stroke and 2,000 deaths from coronary disease, resulting in more than 449,000 person years of life saved and 1.4 billion US$ in direct health care cost savings.[15]
[edit] Gastrointestinal safety
Non-steroidal antiinflammatory drugs have also been associated with gastrointestinal risks such as bleedings. Early studies demonstrated that naproxcinod had a better gastrointestinal profile than naproxen, especially for the gastroduodenal mucosa,[16][17] but a 2009 review has found only a slight and possibly not clinically relevant reduction of gastrointestinal side-effects.[18][19]
[edit] Contraindications and adverse effects
This section requires expansion.
Similarly to NSAIDs, adverse effects of naproxcinod include gastrointestinal bleedings.[18][19]
[edit] Interactions
This section requires expansion.
[edit] Commercialisation
Naproxcinod completed the pivotal phase III studies needed for a New Drug Application (NDA). As a result, NicOx submitted its project to the FDA in September 2009.[20] If the FDA gives its agreement, the commercialisation may begin, with a partner, at the end of 2010.
NicOx has submitted a Marketing Authorization Application (MAA) to the European Medicines Agency (EMEA) in December 2009.[21]
On December 2006, Scientific American distinguished naproxcinod as one of the ten most promising treatments for the world's biggest health threats.[3]
Contents
[hide]
- 1 Current situation in pain treatment
- 2 Indications
- 3 Mechanism of action
- 4 Safety profile
- 5 Contraindications and adverse effects
- 6 Interactions
- 7 Commercialisation
- 8 References
Many people are currently relying on traditional non-steroidal antiinflammatory drugs and COX-2 inhibitors (for example celecoxib) to treat chronic pain and inflammation. COX-2 inhibitors have been associated with an increased risk of serious cardiovascular events such as strokes or heart attacks.[4] Therefore, there is an unmet need for safer medications. This need is particularly acute among patients with high cardiovascular risk like hypertension which represents 50% of osteoarthritis sufferers.[citation needed]
[edit] Indications
Three phase III clinical trials led by NicOx have shown that naproxcinod was effective to treat pain against knee osteoarthritis[5][6][7] and hip osteoarthrtis[8]. A phase II study showed no significant differences in efficacy between naproxcinod and the COX-2 inhibitor rofecoxib in the treatment of pain.[9]
In osteoarthritis, a 750 mg dose is equipotent to 500 mg of naproxen for the treatment of inflammation but with the added benefit of attenuating the cardiovascular effects traditionally associated with NSAIDs.[10]
[edit] Mechanism of action
Naproxcinoid is metabolized to naproxen and a nitric oxide donating moiety. NO has various cardiovascular effects, including vasodilatory and platelet-inhibitory actions as well as the inhibition of vascular smooth muscle proliferation that serves to maintain normal vascular tone.[10]
[edit] Safety profile
[edit] Blood pressure profile
According to some experts[who?], cardiovascular risks induced by COX-2 inhibitors are caused by increases in blood pressure. Naproxcinod demonstrated in a clinical trial with 916 patients to have a blood pressure profile similar to placebo.[10] Two phase II randomized controlled trials have shown a decreased systolic blood pressure by 2.1 mmHg after patients took naproxcinod (375 mg or 750 mg twice daily) for six weeks. These effects were especially pronounced in hypertensive populations.[9][11]
[edit] Clinical relevance of small increase in blood pressure
During an U.S. Food and Drug Administration (FDA) COX-2 advisory committee meeting, doctors have underlined the important role of small increase in blood pressure.[12] They cited the CAMELOT trial which has concluded that even a small decrease in systolic blood pressure of 5 mmHg could lead to a reduction of 31% in cardiovascular events.[13] Clinical studies about rofecoxib have shown that this drug increases the systolic blood pressure.[14]
A 2005 analysis shows that a blood pressure decrease of 3.1 mmHG could avoid over 30,000 deaths from stroke and 2,000 deaths from coronary disease, resulting in more than 449,000 person years of life saved and 1.4 billion US$ in direct health care cost savings.[15]
[edit] Gastrointestinal safety
Non-steroidal antiinflammatory drugs have also been associated with gastrointestinal risks such as bleedings. Early studies demonstrated that naproxcinod had a better gastrointestinal profile than naproxen, especially for the gastroduodenal mucosa,[16][17] but a 2009 review has found only a slight and possibly not clinically relevant reduction of gastrointestinal side-effects.[18][19]
[edit] Contraindications and adverse effects
This section requires expansion.Similarly to NSAIDs, adverse effects of naproxcinod include gastrointestinal bleedings.[18][19]
[edit] Interactions
This section requires expansion.[edit] Commercialisation
Naproxcinod completed the pivotal phase III studies needed for a New Drug Application (NDA). As a result, NicOx submitted its project to the FDA in September 2009.[20] If the FDA gives its agreement, the commercialisation may begin, with a partner, at the end of 2010.
NicOx has submitted a Marketing Authorization Application (MAA) to the European Medicines Agency (EMEA) in December 2009.[21]
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Scusasseroooo......non per fare gli affaracci degli altri.....ma qualcuno sa che fine ha fatto Gigiov e il suo gatto nero ??.......Non vorrei mai che ci perdiamo qualcuno tra i più ottimisti per strada....altrimenti mi tocca passare nelle loro fila per cercare di bilanciare la situazione !!!
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CAZZEGGIANDO QUA E Là.....Investimenti........
Ragazzi...abbiamo sbagliato investimento.........
potevamo comprarlo noi in gruppo anni fa e rivenderlo alla modica cifra richiesta oggi.......1.400.000 euro !!!!
Foto Londra, ecco il garage pi caro del mondo - 1 di 2 - Repubblica.it
P.S. Meno male che è un quartiere chic a Londra........Dovrei cominciare a rivalutare certe vie del quartiere di Quarto Oggiaro a Milano ( chi è della zona sa a che cosa mi riferisco!)
Ragazzi...abbiamo sbagliato investimento.........
potevamo comprarlo noi in gruppo anni fa e rivenderlo alla modica cifra richiesta oggi.......1.400.000 euro !!!!
Foto Londra, ecco il garage pi caro del mondo - 1 di 2 - Repubblica.it
P.S. Meno male che è un quartiere chic a Londra........Dovrei cominciare a rivalutare certe vie del quartiere di Quarto Oggiaro a Milano ( chi è della zona sa a che cosa mi riferisco!)
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Grazie mille.....la vicsim ringrazia la NetzachSim per questa Merger !!!
E ora......se volete seguire un titolo che POTREBBE farvi recuperare i soldi persi sinora con Nicox....sapete dove trovare news e commenti !!!
Netzach
Forumer storico
Grazie mille.....la vicsim ringrazia la Dicksim per questa Merger !!!
E ora......se volete seguire un titolo che POTREBBE farvi recuperare i soldi persi sinora con Nicox....sapete dove trovare news e commenti !!!
Veramente il thread l'ho aperto io ...
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Ragazzi.........dopo una pinta di birra e una sambuca corretta col caffè ( poco il caffè).....mi sono rincoglionito.........
Chiedo venia ai forumers coinvolti !!!
Netzach
Forumer storico
Ragazzi.........dopo una pinta di birra e una sambuca corretta col caffè ( poco il caffè).....mi sono rincoglionito.........
Chiedo venia ai forumers coinvolti !!!
Pizza e birra ???
Buona, specialmente in certi locali e con la compagnia giusta.
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