1. WO WO/2011/160974 - STATIN DERIVATIVES 29.12.2011 C07D 207/34 PCT/EP2011/059778 NICOX S.A. STORONI, Laura
Dinitrate statins having improved pharmacological activity are described. They can be employed for treating and/or preventing several diseases, in particular acute coronary syndromes, neurodegenerative disorders as well as for reducing cholesterol levels.
The present invention relates to new statin nitroderivatives . More particularly, the present invention relates to dinitrate statins, pharmaceutical compositions containing them and their use as cholesterol-reducing drugs, as drugs having antioxidant, antithrombotic and anti-inflammatory activity, effects on endothelial function, immunosuppressive properties and for treating and/or preventing acute coronary syndromes, stroke, neurodegenerative disorders, such as Alzheimer's and Parkinson's disease as well as autoimmune diseases, such as multiple sclerosis.